Topic: Recent Progress on Phototherapy and Fluorescent Imaging Probes

Speaker: Prof. Juyoung Yoon

Host: Prof. Ben Zhong Tang

Date: January 25, 2024 (Thursday)

Time: 3:30 pm – 4:30 pm

Venue: TD 102

Language: English

Abstract:

The development of fluorescent probes for various analytes has been actively pursued by chemists. Recently, a near-infrared two-photon fluorescent probe was developed to not only specially image carboxylesterase (CE) activity in vivo and in situ but also target orthotopic liver tumor after systemic administration.¹

On the other hand, photodynamic therapy (PDT) and photothermal therapy (PTT) have attracted considerable interest as a noninvasive treatment method. We devised a novel molecular design approach to create heavy-atom-free photosensitizers for thionapthalimides.² The in vivo specific binding between albumin and PcS, arising from the disassembly of injected NanoPcS, was also confirmed using an inducible transgenic mouse system.³

Photodynamic antibacterial therapy is also regarded as an innovative and promising antibacterial approach due to its minor side effects and lack of drug resistance.⁴ Recently, we suggested that reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-positive bacteria-infected diseases.⁵

1. X. Wu, R. Wang, S. Qi, N. Kwon, J. Han, H. Kim, H. Li, F. Yu and J. Yoon, Angew. Chem. Int. Ed., 2021, 60, 15418.

2. V.-N. Nguyen, S. Qi, S. Kim, N. Kwon, G. Kim, Y. Yim, S. Park and J. Yoon, J. Am. Chem. Soc., 2019, 141, 16243.

3. X. Li, S. Yu, Y. Lee, T. Guo, N. Kwon, D. Lee, S. C. Yeom, Y. Cho, G. Kim, J.-D. Huang, S. Choi, K. T. Nam and J. Yoon, J. Am. Chem. Soc., 2019, 141, 1366.

4. V.-N. Nguyen, Z. Zhao, B. Z. Tang and J. Yoon, Chem. Soc. Rev., 2022, 51, 3324.

5. X. Wu, M. Yang, J. S. Kim, R. Wang, G. Kim, J. Ha, H. Kim, Y. Cho, K. T. Nam and J. Yoon, Angew. Chem. Int. Ed., 2022, 61, e202200808.

Speaker Profile:

Juyoung Yoon received his Ph.D. (1994) from The Ohio State University. After completing postdoctoral research at the University of California, Los Angeles and at The Scripps Research Institute, he joined the faculty at Silla University in 1998. In 2002, he moved to Ewha Womans University, where he is currently Professor of Department of Chemistry and Nanoscience. He is a member of Korean Academy of Science and Technology, Fellow of Royal Society of Chemistry and currently a Distinguished Professor of Ewha. He is serving as an Associate Editor of Coordination Chemical Reviews and Smart Molecules and as an Executive Editor of Dyes and Pigments. He is also serving as an Advisory Editorial Board Member of Chemical Society Reviews (Royal Society of Chemistry, UK), Chem (Cell Press), ACS Applied Materials & Interfaces (ACS), ACS Sensors (ACS), Sensors and Actuators B (Elsevier), ACS Omega (ACS), ACS Applied Bio Materials (ACS), Materials Chemistry Frontiers (RSC), Chinese Chemical Letters (Elsevier), Aggregate (Wiley) and ACS Measurement Science Au (ACS). He published 465 SCI research papers (h-index: 125).

His scientific awards include “Knowledge Creation Grand Prize” by Ministry of Science and Technology of Korea (2012), Korean Chemical Society Award (2016), Ewha Academic Award (2016), 2^nd Korea Toray Science Award (2019), 13^th Kyung-Ahm Academic Award (2020) and MSMLG Carnik Award (2022).

He was listed as highly cited researcher in chemistry of 2014-2023.